Director Jean-Jacques Annaud sent a team to Tibet to secretly film footage. About 20 minutes of it made it into the finished film. This was kept secret even after the film's premiere and not known until summer 1999.
Jetsun Pema is the real-life sister of the Dalai Lama. In this film she plays the mother of the Dalai Lama and hence her own mother.
Because of their roles in the movie, David Thewlis and Brad Pitt are banned from ever entering China.
In the scene where Heinrich confronts Ngawang, the director did not tell B.D. Wong the script called for Brad Pitt to throw him into the dirt; Wong's reaction is completely authentic.
Brad Pitt was paid $8 million for appearing in the film.