A wraith kills her friend and Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, and could be next on the wraith's hit list. Sam continues to work with Jack to control his powers.
When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.
Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.
Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dream catcher named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.